HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzenesulfonyl chloride → 8-Benzenesulfonyl-2-[6-(2,2,2-trifluoro-ethoxy)-pyridin-3-yl]-2,8-diaza-spiro[4.5]decan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzenesulfonyl chloride | HCID 7369 | — |
| Reactant | 6-(2,2,2-Trifluoroethoxy)pyridin-3-amine | HCID 543156 | — |
| Reactant | 4-(2-Methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester | HCID 56753969 | — |
| Product | 8-Benzenesulfonyl-2-[6-(2,2,2-trifluoro-ethoxy)-pyridin-3-yl]-2,8-diaza-spiro[4.5]decan-1-one | HCID 59577892 | — |
Reaction Steps
Light brown crystalline solid. MS (ESI): 470.3. (MH+). This example was prepared in analogy to example 1 step C) to D) from 4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester (example 1 step B)), benzenesulfonyl chloride and 6-(2,2,2-trifluoro-ethoxy)-pyridin-3-ylamine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08329904B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-91467f278edf4ef2aa84a4a945604300 |
| Source note | uspto-grants-2012_12 |