2-Chlorobenzenesulfonyl chloride → 8-(2-Chloro-benzenesulfonyl)-2-[6-(2,2,2-trifluoro-ethoxy)-pyridin-3-yl]-2,8-diaza-spiro[4.5]decan-1-one
Reaction equation
C(O[C:4]([C:6]1([CH2:12][CH2:13]OC)[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)=[O:5])C.[Cl:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[S:23](Cl)(=[O:25])=[O:24].[F:27][C:28]([F:39])([F:38])[CH2:29][O:30][C:31]1[N:36]=[CH:35][C:34]([NH2:37])=[CH:33][CH:32]=1>>[Cl:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[S:23]([N:9]1[CH2:8][CH2:7][C:6]2([C:4](=[O:5])[N:37]([C:34]3[CH:35]=[N:36][C:31]([O:30][CH2:29][C:28]([F:39])([F:27])[F:38])=[CH:32][CH:33]=3)[CH2:13][CH2:12]2)[CH2:11][CH2:10]1)(=[O:25])=[O:24]Participants
4
Reactant 3
Product 1
Procedure
Off-white crystalline solid. MS (ESI): 504.1. (MH+). This example was prepared in analogy to example 1 step C) to D) from 4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester (example 1 step B)), 2-chlorobenzenesulfonyl chlorid and 6-(2,2,2-trifluoro-ethoxy)-pyridin-3-ylamine.
Sources & evidence
- ORD record
- ord-ccdedac9c18647d08f4ecf57a7370385
- Source dataset
- uspto-grants-2012_12
- Patent number
- US08329904B2
Reaction notes
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