2,2-Dichloro-1-methylcyclopropanecarboxylic acid → HCID 59577942, compound

HRID 2194103Notes

Reaction equation

HRID 2194103 reaction equation
C(O[C:4]([C:6]1([CH2:12][CH2:13]OC)[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)=[O:5])C.[Cl:16][C:17]1([Cl:24])[CH2:19][C:18]1([CH3:23])[C:20](O)=[O:21].[F:25][C:26]([F:37])([F:36])[CH2:27][O:28][C:29]1[CH:34]=[CH:33][C:32]([NH2:35])=[CH:31][CH:30]=1>>[Cl:16][C:17]1([Cl:24])[CH2:19][C:18]1([CH3:23])[C:20]([N:9]1[CH2:8][CH2:7][C:6]2([C:4](=[O:5])[N:35]([C:32]3[CH:33]=[CH:34][C:29]([O:28][CH2:27][C:26]([F:25])([F:36])[F:37])=[CH:30][CH:31]=3)[CH2:13][CH2:12]2)[CH2:11][CH2:10]1)=[O:21]

Participants

4

Reactant 3

HCID 1026212,2-Dichloro-1-methylcyclopropanecarboxylic acidHCID 27771194-(2,2,2-Trifluoroethoxy)anilineHCID 567539694-(2-Methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester

Product 1

HCID 59577942HCID 59577942, compound

Procedure

Brown crystalline solid. MS (ESI): 480.2 (MH+). This example was prepared in analogy to example 13 step A) to B) from 4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester (example 1 step B)), 2,2-dichloro-1-methyl-cyclopropanecarboxylic acid, 4-(2,2,2-trifluoro-ethoxy)-phenylamine.

Sources & evidence

ORD record
ord-1c193b4f386444a2be328904c94a8042
Source dataset
uspto-grants-2012_12
Patent number
US08329904B2

Reaction notes

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