2-Chlorobenzenesulfonyl chloride → HCID 59578023, compound

HRID 2194112Notes

Reaction equation

HRID 2194112 reaction equation
C(O[C:4]([C:6]1([CH2:12][CH2:13]OC)[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)=[O:5])C.[Cl:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[S:23](Cl)(=[O:25])=[O:24].[CH3:27][N:28]1[CH:36]=[C:35]2[C:30]([CH:31]=[CH:32][C:33]([NH2:37])=[CH:34]2)=[N:29]1>>[Cl:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[S:23]([N:9]1[CH2:8][CH2:7][C:6]2([C:4](=[O:5])[N:37]([C:33]3[CH:32]=[CH:31][C:30]4[C:35](=[CH:36][N:28]([CH3:27])[N:29]=4)[CH:34]=3)[CH2:13][CH2:12]2)[CH2:11][CH2:10]1)(=[O:25])=[O:24]

Participants

4

Reactant 3

HCID 761872-Chlorobenzenesulfonyl chlorideHCID 14912522-methyl-2H-indazol-5-amineHCID 567539694-(2-Methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester

Product 1

HCID 59578023HCID 59578023, compound

Procedure

Off-white crystalline solid. MS (ESI): 459.3 (MH+). This example was prepared in analogy to example 1 step C) to D) from 4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester (example 1 step B)), 2-chlorobenzenesulfonyl chloride and 2-methyl-2H-indazol-5-ylamine (synthesis: Boyer, et al; Journal of Chemical Research, Miniprint; English; 11; 1990; 2601).

Sources & evidence

ORD record
ord-2ab85fbe8bd04cafbc3c7bb4bc0e94c3
Source dataset
uspto-grants-2012_12
Patent number
US08329904B2

Reaction notes

Loading…