Hydrochloric Acid → HCID 59578004, compound

Participants

Reaction Steps

4-[8-(2-Chloro-benzenesulfonyl)-1-oxo-2,8-diaza-spiro[4.5]dec-2-yl]-benzoic acid (0.5 g) was dissolved in THF under an argon atmosphere and then treated at 0° C. with borane THF complex (1 molar, 6.68 ml) and stirred overnight at RT. Then 1M aqueous HCl (1 ml) was added and the mixture was stirred for 10 minutes. The solvent was evaporated off in vacuo, the residue was adsorbed on silica gel and chromatographed over silica gel (AcOEt/heptane, gradient from 0 to 50%) to give the desired 8-(2-chloro-benzenesulfonyl)-2-(4-hydroxymethyl-phenyl)-2,8-diaza-spiro[4.5]decan-1-one as a white solid. MS (ESI): 435.3 (MH+).

Provenance & Evidence