HCID 59578062, compound → HCID 59578064, compound

HRID 2194125Notes

Reaction equation

HRID 2194125 reaction equation
[CH3:1][O:2][CH2:3]/[CH:4]=[CH:5]/[C:6]1[CH:11]=[CH:10][C:9]([N:12]2[CH2:16][CH2:15][C:14]3([CH2:21][CH2:20][N:19]([S:22]([C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=4[O:31][C:32]([F:35])([F:34])[F:33])(=[O:24])=[O:23])[CH2:18][CH2:17]3)[C:13]2=[O:36])=[CH:8][CH:7]=1>CO.[Pd]>[CH3:1][O:2][CH2:3][CH2:4][CH2:5][C:6]1[CH:7]=[CH:8][C:9]([N:12]2[CH2:16][CH2:15][C:14]3([CH2:21][CH2:20][N:19]([S:22]([C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=4[O:31][C:32]([F:33])([F:34])[F:35])(=[O:23])=[O:24])[CH2:18][CH2:17]3)[C:13]2=[O:36])=[CH:10][CH:11]=1

Participants

4

Reactant 1

HCID 59578062HCID 59578062, compound2×

Product 1

HCID 59578064HCID 59578064, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

2-[4-((E)-3-Methoxy-propenyl)-phenyl]-8-(2-trifluoromethoxy-benzenesulfonyl)-2,8-diaza-spiro[4.5]decan-1-one (0.07 g), product of example 144), in methanol (10 ml) was hydrogenated over Pd on charcoal (10%) at atmospheric pressure for 12 h. The catalyst was removed by filtration, the solvent evaporated off to give the desired material as white solid. MS (ESI): 527.18 (MH+).

Workup

  1. customThe catalyst was removed by filtration
  2. customthe solvent evaporated off

Sources & evidence

ORD record
ord-ba66f0c65e50434583651cc69b763eee
Source dataset
uspto-grants-2012_12
Patent number
US08329904B2

Reaction notes

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