2,2,2-Trifluoro-1-(4-iodophenyl)ethanol → 8-(Isobutylsulfonyl)-2-(4-(2,2,2-trifluoro-1-hydroxyethyl)phenyl)-2,8-diazaspiro[4.5]decan-1-one

HRID 2194148Notes

Reaction equation

HRID 2194148 reaction equation
[CH2:1]([S:5]([N:8]1[CH2:18][CH2:17][C:11]2([C:15](=[O:16])[NH:14][CH2:13][CH2:12]2)[CH2:10][CH2:9]1)(=[O:7])=[O:6])[CH:2]([CH3:4])[CH3:3].[F:19][C:20]([F:31])([F:30])[CH:21]([C:23]1[CH:28]=[CH:27][C:26](I)=[CH:25][CH:24]=1)[OH:22]>>[CH2:1]([S:5]([N:8]1[CH2:18][CH2:17][C:11]2([C:15](=[O:16])[N:14]([C:26]3[CH:27]=[CH:28][C:23]([CH:21]([OH:22])[C:20]([F:30])([F:31])[F:19])=[CH:24][CH:25]=3)[CH2:13][CH2:12]2)[CH2:10][CH2:9]1)(=[O:6])=[O:7])[CH:2]([CH3:4])[CH3:3]

Participants

3

Reactant 2

HCID 594408652,2,2-Trifluoro-1-(4-iodophenyl)ethanolHCID 595779518-(Isobutylsulfonyl)-2,8-diazaspiro[4.5]decan-1-one

Product 1

HCID 595780298-(Isobutylsulfonyl)-2-(4-(2,2,2-trifluoro-1-hydroxyethyl)phenyl)-2,8-diazaspiro[4.5]decan-1-one

Procedure

This material was prepared In analogy to example 162 B) from 8-(isobutylsulfonyl)-2,8-diazaspiro[4.5]decan-1-one and 2,2,2-trifluoro-1-(4-iodo-phenyl)-ethanol. White solid. MS (ESI): 449.17 MH+).

Sources & evidence

ORD record
ord-614c885306f9466fa633945521369126
Source dataset
uspto-grants-2012_12
Patent number
US08329904B2

Reaction notes

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