HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,1,1-Trifluoro-2-(4-iodo-phenyl)-propan-2-ol → 8-(Isobutylsulfonyl)-2-(4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenyl)-2,8-diazaspiro[4.5]decan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,1,1-Trifluoro-2-(4-iodo-phenyl)-propan-2-ol | HCID 15134939 | — |
| Reactant | 8-(Isobutylsulfonyl)-2,8-diazaspiro[4.5]decan-1-one | HCID 59577951 | — |
| Reactant | 8-(Isobutylsulfonyl)-2-(4-(2,2,2-trifluoro-1-hydroxyethyl)phenyl)-2,8-diazaspiro[4.5]decan-1-one | HCID 59578029 | — |
| Product | 8-(Isobutylsulfonyl)-2-(4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenyl)-2,8-diazaspiro[4.5]decan-1-one | HCID 59577985 | — |
Reaction Steps
This material was prepared in analogy to example 162 step B) from 8-(isobutylsulfonyl)-2,8-diazaspiro[4.5]decan-1-one, product of example 167 A) and 1,1,1-trifluoro-2-(4-iodo-phenyl)-propan-2-ol (synthesis: H. Urata et al, Tetrahedron Letters; 1991; p 91). White crystalline solid. MS (ESI): 463.2 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08329904B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-57920884eaf14f5683351b1f3822d581 |
| Source note | uspto-grants-2012_12 |