1,1,1-Trifluoro-2-(4-iodo-phenyl)-propan-2-ol → 8-(Cyclopropylsulfonyl)-2-(4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenyl)-2,8-diazaspiro[4.5]decan-1-one

HRID 2194152Notes

Reaction equation

HRID 2194152 reaction equation
[CH:1]1([S:4]([N:7]2[CH2:17][CH2:16][C:10]3([C:14](=[O:15])[NH:13][CH2:12][CH2:11]3)[CH2:9][CH2:8]2)(=[O:6])=[O:5])[CH2:3][CH2:2]1.C1(S(N2CCC3(C(=O)N(C4C=CC(C(O)C(F)(F)F)=CC=4)CC3)CC2)(=O)=O)CC1.[F:47][C:48]([F:60])([F:59])[C:49]([C:52]1[CH:57]=[CH:56][C:55](I)=[CH:54][CH:53]=1)([OH:51])[CH3:50]>>[CH:1]1([S:4]([N:7]2[CH2:17][CH2:16][C:10]3([C:14](=[O:15])[N:13]([C:55]4[CH:56]=[CH:57][C:52]([C:49]([OH:51])([CH3:50])[C:48]([F:59])([F:60])[F:47])=[CH:53][CH:54]=4)[CH2:12][CH2:11]3)[CH2:9][CH2:8]2)(=[O:5])=[O:6])[CH2:3][CH2:2]1

Participants

4

Reactant 3

HCID 151349391,1,1-Trifluoro-2-(4-iodo-phenyl)-propan-2-olHCID 595779488-(Cyclopropylsulfonyl)-2,8-diazaspiro[4.5]decan-1-oneHCID 595779698-(Cyclopropylsulfonyl)-2-(4-(2,2,2-trifluoro-1-hydroxyethyl)phenyl)-2,8-diazaspiro[4.5]decan-1-one

Product 1

HCID 595779758-(Cyclopropylsulfonyl)-2-(4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenyl)-2,8-diazaspiro[4.5]decan-1-one

Procedure

This material was prepared In analogy to example 162 step B) from 8-(cyclopropylsulfonyl)-2,8-diazaspiro[4.5]decan-1-one, product of example 170 A) and 1,1,1-trifluoro-2-(4-iodo-phenyl)-propan-2-ol). Pink crystalline solid. MS (ESI): 447.15 (MH+).

Sources & evidence

ORD record
ord-33bb13e2f5e2434faefa38e87a9c4ceb
Source dataset
uspto-grants-2012_12
Patent number
US08329904B2

Reaction notes

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