HRID2194153

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID53996144

未命名化合物

结构：O=C1NCCC12CCN(S(=O)(=O)c1ccccc1C(F)(F)F)CC2

HCID59577926

未命名化合物

结构：O=C1N(c2ccc(C(O)C(F)(F)F)cc2)CCC12CCN(S(=O)(=O)c1ccccc1C(F)(F)F)CC2

HCID59577944

未命名化合物

PRODUCTS

生成物

结构：CC(C)(O)c1ccc(N2CCC3(CCN(S(=O)(=O)c4ccccc4C(F)(F)F)CC3)C2=O)cc1

HCID59577891

未命名化合物

PROCEDURE

实验过程

This material was prepared In analogy to example 162 step B) from 8-(2-trifluoromethyl-benzenesulfonyl)-2,8-diaza-spiro[4.5]decan-1-one, product of example 166 A) and 2-(4-iodo-phenyl)-propan-2-ol (synthesis: Brown et al.; JACS; 79; 1957, p 1906). Light yellow solid. MS (ESI): 497.17 (MH+).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-acf0b2c785e140fa96e209fcef4c145b
来源数据集: uspto-grants-2012_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08329904B2
来源说明: uspto-grants-2012_12

反应 SMILES

[F:1][C:2]([F:24])([F:23])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[S:9]([N:12]1[CH2:22][CH2:21][C:15]2([C:19](=[O:20])[NH:18][CH2:17][CH2:16]2)[CH2:14][CH2:13]1)(=[O:11])=[O:10].FC(F)(F)C(C1C=CC(N2CCC3(CCN(S(C4C=CC=CC=4C(F)(F)F)(=O)=O)CC3)C2=O)=CC=1)O.I[C:62]1[CH:67]=[CH:66][C:65]([C:68]([OH:71])([CH3:70])[CH3:69])=[CH:64][CH:63]=1>>[OH:71][C:68]([C:65]1[CH:66]=[CH:67][C:62]([N:18]2[CH2:17][CH2:16][C:15]3([CH2:21][CH2:22][N:12]([S:9]([C:4]4[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=4[C:2]([F:1])([F:23])[F:24])(=[O:11])=[O:10])[CH2:13][CH2:14]3)[C:19]2=[O:20])=[CH:63][CH:64]=1)([CH3:70])[CH3:69]