HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-Bromo-phenyl)-2,2-difluoro-propan-1-ol → 2-(4-(2,2-Difluoro-1-hydroxypropyl)phenyl)-8-(3,3-dimethylbutanoyl)-2,8-diazaspiro[4.5]decan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-Bromo-phenyl)-2,2-difluoro-propan-1-ol | HCID 23729514 | — |
| Reactant | 8-(3,3-Dimethyl-butyryl)-2-[4-(2,2,2-trifluoro-1-hydroxy-ethyl)-phenyl]-2,8-diaza-spiro[4.5]decan-1-one | HCID 59577894 | — |
| Reactant | 8-(3,3-Dimethyl-butyryl)-2,8-diaza-spiro[4.5]decan-1-one | HCID 59578014 | — |
| Product | 2-(4-(2,2-Difluoro-1-hydroxypropyl)phenyl)-8-(3,3-dimethylbutanoyl)-2,8-diazaspiro[4.5]decan-1-one | HCID 59577905 | — |
Reaction Steps
This material was prepared In analogy to example 162 step B) from 8-(3,3-dimethyl-butyryl)-2,8-diaza-spiro[4.5]decan-1-one, product of example 165 A) and 1-(4-bromo-phenyl)-2,2-difluoro-propan-1-ol (synthesis: R. Mogi, et al, Journal of Fluorine Chemistry; 10; 2007; p 1098). White solid. MS (ESI): 423.24 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08329904B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-0557d2fe765448f2b2a90ba0927c1e62 |
| Source note | uspto-grants-2012_12 |