1-(4-Bromophenyl)-2,2-difluoroethan-1-ol → 2-(4-(2,2-Difluoro-1-hydroxyethyl)phenyl)-8-(isobutylsulfonyl)-2,8-diazaspiro[4.5]decan-1-one

HRID 2194155Notes

Reaction equation

HRID 2194155 reaction equation
C(S(N1CCC2(C(=O)NCC2)CC1)(=O)=O)C(C)C.[CH2:19]([S:23]([N:26]1[CH2:48][CH2:47][C:29]2([C:33](=[O:34])[N:32]([C:35]3[CH:40]=[CH:39][C:38]([CH:41]([OH:46])[C:42](F)([F:44])[F:43])=[CH:37][CH:36]=3)[CH2:31][CH2:30]2)[CH2:28][CH2:27]1)(=[O:25])=[O:24])[CH:20]([CH3:22])[CH3:21].BrC1C=CC(C(O)C(F)F)=CC=1>>[F:44][CH:42]([F:43])[CH:41]([C:38]1[CH:37]=[CH:36][C:35]([N:32]2[CH2:31][CH2:30][C:29]3([CH2:47][CH2:48][N:26]([S:23]([CH2:19][CH:20]([CH3:22])[CH3:21])(=[O:24])=[O:25])[CH2:27][CH2:28]3)[C:33]2=[O:34])=[CH:40][CH:39]=1)[OH:46]

Participants

4

Reactant 3

HCID 159422041-(4-Bromophenyl)-2,2-difluoroethan-1-olHCID 595779518-(Isobutylsulfonyl)-2,8-diazaspiro[4.5]decan-1-oneHCID 595780298-(Isobutylsulfonyl)-2-(4-(2,2,2-trifluoro-1-hydroxyethyl)phenyl)-2,8-diazaspiro[4.5]decan-1-one

Product 1

HCID 595780952-(4-(2,2-Difluoro-1-hydroxyethyl)phenyl)-8-(isobutylsulfonyl)-2,8-diazaspiro[4.5]decan-1-one

Procedure

This material was prepared In analogy to example 162 step B) from 8-(isobutylsulfonyl)-2,8-diazaspiro[4.5]decan-1-one, product of example 167 A) and 1-(4-bromo-phenyl)-2,2-difluoro-ethanol, described in example 176). Light yellow solid. MS (ESI): 431.18 (MH+).

Sources & evidence

ORD record
ord-00b56e2c60404eb398c74b889d4c63be
Source dataset
uspto-grants-2012_12
Patent number
US08329904B2

Reaction notes

Loading…