1-Pyrrolidinesulfonyl chloride → 8-(Pyrrolidine-1-sulfonyl)-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one

HRID 2194163Notes

Reaction equation

HRID 2194163 reaction equation
C(O)(=O)C.[F:5][C:6]([F:26])([F:25])[O:7][C:8]1[CH:13]=[CH:12][C:11]([N:14]2[CH2:18][CH2:17][C:16]3([CH2:23][CH2:22][NH:21][CH2:20][CH2:19]3)[C:15]2=[O:24])=[CH:10][CH:9]=1.[N:27]1([S:32](Cl)(=[O:34])=[O:33])[CH2:31][CH2:30][CH2:29][CH2:28]1>>[N:27]1([S:32]([N:21]2[CH2:20][CH2:19][C:16]3([C:15](=[O:24])[N:14]([C:11]4[CH:12]=[CH:13][C:8]([O:7][C:6]([F:5])([F:25])[F:26])=[CH:9][CH:10]=4)[CH2:18][CH2:17]3)[CH2:23][CH2:22]2)(=[O:34])=[O:33])[CH2:31][CH2:30][CH2:29][CH2:28]1

Participants

3

Reactant 2

HCID 64839021-Pyrrolidinesulfonyl chlorideHCID 667873332-(4-Trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one acetic acid salt

Product 1

HCID 595780318-(Pyrrolidine-1-sulfonyl)-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one

Procedure

The title compound was prepared in analogy to example 180 step D from 2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one acetic acid salt (described in example 180 step C) and pyrrolidine-1-sulfonyl chloride. Off-white solid. MS (ESI): 448.2 (MH+).

Sources & evidence

ORD record
ord-1b4c872650194be2bb0e72ecff3a8a36
Source dataset
uspto-grants-2012_12
Patent number
US08329904B2

Reaction notes

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