2-Chloropyridine-3-sulfonyl chloride → 8-(2-Chloro-pyridine-3-sulfonyl)-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one

HRID 2194169Notes

Reaction equation

HRID 2194169 reaction equation
[F:1][C:2]([F:22])([F:21])[O:3][C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:14][CH2:13][C:12]3([CH2:19][CH2:18][NH:17][CH2:16][CH2:15]3)[C:11]2=[O:20])=[CH:6][CH:5]=1.[Cl:23][C:24]1[C:29]([S:30](Cl)(=[O:32])=[O:31])=[CH:28][CH:27]=[CH:26][N:25]=1>>[Cl:23][C:24]1[C:29]([S:30]([N:17]2[CH2:16][CH2:15][C:12]3([C:11](=[O:20])[N:10]([C:7]4[CH:8]=[CH:9][C:4]([O:3][C:2]([F:1])([F:21])[F:22])=[CH:5][CH:6]=4)[CH2:14][CH2:13]3)[CH2:19][CH2:18]2)(=[O:32])=[O:31])=[CH:28][CH:27]=[CH:26][N:25]=1

Participants

3

Reactant 2

HCID 102199682-Chloropyridine-3-sulfonyl chlorideHCID 667427592-(4-(Trifluoromethoxy)phenyl)-2,8-diazaspiro[4.5]decan-1-one

Product 1

HCID 595779608-(2-Chloro-pyridine-3-sulfonyl)-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one

Procedure

The title compound was prepared in analogy to example 180 step D from 2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one (described in example 180 step C) and 2-chloro-pyridine-3-sulfonyl chloride. White solid. MS (ESI): 490.2 (MH+)

Sources & evidence

ORD record
ord-ae75ac76ebd24ad7a0ee027ebeb28d6c
Source dataset
uspto-grants-2012_12
Patent number
US08329904B2

Reaction notes

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