HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanolamine → 8-[2-(2-Hydroxy-ethylamino)-pyridine-3-sulfonyl]-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanolamine | HCID 700 | — |
| Reactant | 8-(2-Chloro-pyridine-3-sulfonyl)-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one | HCID 59577960 | — |
| Product | 8-[2-(2-Hydroxy-ethylamino)-pyridine-3-sulfonyl]-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one | HCID 59577978 | — |
Reaction Steps
The title compound was prepared in analogy to example 189 from 8-(2-chloro-pyridine-3-sulfonyl)-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one (described in example 188) and ethanolamine. White gum. MS (ESI): 515.3 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08329904B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-1beef53570b746469dbc27a7c7807c5d |
| Source note | uspto-grants-2012_12 |