2-Chloropyridine-3-sulfonyl chloride → HCID 59578053, compound

HRID 2194183Notes

Reaction equation

HRID 2194183 reaction equation
[F:1][C:2]([F:23])([F:22])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([N:11]2[CH2:15][CH2:14][C:13]3([CH2:20][CH2:19][NH:18][CH2:17][CH2:16]3)[C:12]2=[O:21])=[CH:7][CH:6]=1.[Cl:24][C:25]1[C:30]([S:31](Cl)(=[O:33])=[O:32])=[CH:29][CH:28]=[CH:27][N:26]=1>>[Cl:24][C:25]1[C:30]([S:31]([N:18]2[CH2:17][CH2:16][C:13]3([C:12](=[O:21])[N:11]([C:8]4[CH:9]=[CH:10][C:5]([O:4][CH2:3][C:2]([F:1])([F:22])[F:23])=[CH:6][CH:7]=4)[CH2:15][CH2:14]3)[CH2:20][CH2:19]2)(=[O:33])=[O:32])=[CH:29][CH:28]=[CH:27][N:26]=1

Participants

3

Reactant 2

HCID 102199682-Chloropyridine-3-sulfonyl chlorideHCID 58287275HCID 58287275, compound

Product 1

HCID 59578053HCID 59578053, compound

Procedure

The title compound was prepared in analogy to example 180 step D from 2-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-2,8-diaza-spiro[4.5]decan-1-one (prepared in analogy to example 180 step B-D using 1-benzyl-4-(2-methoxyethyl)-piperidine-4-carboxylic acid ethyl ester and 4-(2,2,2-trifluoro-ethoxy)aniline) and 2-chloro-pyridine-3-sulfonyl chloride. White solid. MS (ESI): 504.1 (MH+).

Sources & evidence

ORD record
ord-89a9de2372134fa98e716ea3e57110a6
Source dataset
uspto-grants-2012_12
Patent number
US08329904B2

Reaction notes

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