8-Methanesulfonyl-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one → 8-(2-Hydroxy-2-methyl-propane-1-sulfonyl)-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one

HRID 2194190Notes

Reaction equation

HRID 2194190 reaction equation
[CH3:1][S:2]([N:5]1[CH2:26][CH2:25][C:8]2([C:12](=[O:13])[N:11]([C:14]3[CH:19]=[CH:18][C:17]([O:20][C:21]([F:24])([F:23])[F:22])=[CH:16][CH:15]=3)[CH2:10][CH2:9]2)[CH2:7][CH2:6]1)(=[O:4])=[O:3]>CC(=O)C>[OH:20][C:17]([CH3:18])([CH3:16])[CH2:1][S:2]([N:5]1[CH2:6][CH2:7][C:8]2([C:12](=[O:13])[N:11]([C:14]3[CH:15]=[CH:16][C:17]([O:20][C:21]([F:23])([F:22])[F:24])=[CH:18][CH:19]=3)[CH2:10][CH2:9]2)[CH2:25][CH2:26]1)(=[O:4])=[O:3]

Participants

3

Reactant 1

HCID 595779498-Methanesulfonyl-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one

Product 1

HCID 595780708-(2-Hydroxy-2-methyl-propane-1-sulfonyl)-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

The title compound was prepared in analogy to example 208 step B from 8-methanesulfonyl-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one (described in example 208, step A) and propan-2-one. White solid. MS (ESI): 451.2 (MH+).

Sources & evidence

ORD record
ord-d5d6f8f2ef3d42469d4da6834df4ede8
Source dataset
uspto-grants-2012_12
Patent number
US08329904B2

Reaction notes

Loading…