HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(4-Bromophenyl)oxetan-3-ol → 8-(2-Chloro-benzenesulfonyl)-2-[4-(3-hydroxy-oxetan-3-yl)-phenyl]-2,8-diaza-spiro[4.5]decan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(4-Bromophenyl)oxetan-3-ol | HCID 58382379 | — |
| Reactant | 8-(2-Chloro-benzenesulfonyl)-2,8-diaza-spiro[4.5]decan-1-one | HCID 59577994 | — |
| Product | 8-(2-Chloro-benzenesulfonyl)-2-[4-(3-hydroxy-oxetan-3-yl)-phenyl]-2,8-diaza-spiro[4.5]decan-1-one | HCID 59577907 | — |
Reaction Steps
The title compound was prepared in analogy to example 148 step F) from 8-(2-chloro-benzenesulfonyl)-2,8-diaza-spiro[4.5]decan-1-one (described in example 148 step E or example 179 step A for an alternative synthesis) and 3-(4-bromo-phenyl)-oxetan-3-ol (prepared as described in WO 2008/156726). White solid. MS (ESI): 477.1 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08329904B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-c5a12d035d9e45ecb2849e763f807cdc |
| Source note | uspto-grants-2012_12 |