p-Fluorophenethylamine → 8-(2-Chloro-benzenesulfonyl)-2-[2-(4-fluoro-phenyl)-ethyl]-2,8-diaza-spiro[4.5]decan-1-one

HRID 2194217Notes

Reaction equation

HRID 2194217 reaction equation
C(O[C:4]([C:6]1([CH2:22][CH2:23]OC)[CH2:11][CH2:10][N:9]([S:12]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[Cl:21])(=[O:14])=[O:13])[CH2:8][CH2:7]1)=[O:5])C.[Cl-].C[Al+]C.[F:30][C:31]1[CH:36]=[CH:35][C:34]([CH2:37][CH2:38][NH2:39])=[CH:33][CH:32]=1>C1(C)C=CC=CC=1>[Cl:21][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=1[S:12]([N:9]1[CH2:8][CH2:7][C:6]2([C:4](=[O:5])[N:39]([CH2:38][CH2:37][C:34]3[CH:35]=[CH:36][C:31]([F:30])=[CH:32][CH:33]=3)[CH2:23][CH2:22]2)[CH2:11][CH2:10]1)(=[O:13])=[O:14]

Participants

5

Reactant 3

HCID 4653p-FluorophenethylamineHCID 16686359Dimethylalumanylium chlorideHCID 667876761-(2-Chloro-benzenesulfonyl)-4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester

Product 1

HCID 595779928-(2-Chloro-benzenesulfonyl)-2-[2-(4-fluoro-phenyl)-ethyl]-2,8-diaza-spiro[4.5]decan-1-one

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

This material was prepared in analogy to example 1 step D) from 1-(2-chloro-benzenesulfonyl)-4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester, dimethylaluminium chloride in toluene and 2-(4-Fluoro-phenyl)-ethylamine. MS (ESI): 451.3 (MH+).

Sources & evidence

ORD record
ord-2f472ba72e99489f932b422a2ea15c50
Source dataset
uspto-grants-2012_12
Patent number
US08329904B2

Reaction notes

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