HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(2-Chlorophenyl)ethylamine → 8-(2-Chloro-benzenesulfonyl)-2-[2-(2-chloro-phenyl)-ethyl]-2,8-diaza-spiro[4.5]decan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(2-Chlorophenyl)ethylamine | HCID 83117 | — |
| Reactant | Dimethylalumanylium chloride | HCID 16686359 | — |
| Reactant | 1-(2-Chloro-benzenesulfonyl)-4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester | HCID 66787676 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 8-(2-Chloro-benzenesulfonyl)-2-[2-(2-chloro-phenyl)-ethyl]-2,8-diaza-spiro[4.5]decan-1-one | HCID 59577974 | — |
Reaction Steps
This material was prepared in analogy to example 1 step D) from 1-(2-chloro-benzenesulfonyl)-4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester, dimethylaluminium chloride in toluene and 2-(2-Chloro-phenyl)-ethylamine. MS (ESI): 467.3 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08329904B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-62a6a1aa9ff245d6b2238681a6fa408c |
| Source note | uspto-grants-2012_12 |