HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Ethylpyridin-3-amine → 8-(2-Chloro-benzenesulfonyl)-2-(6-ethyl-pyridin-3-yl)-2,8-diaza-spiro[4.5]decan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Ethylpyridin-3-amine | HCID 13860729 | — |
| Reactant | Dimethylalumanylium chloride | HCID 16686359 | — |
| Reactant | 1-(2-Chloro-benzenesulfonyl)-4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester | HCID 66787676 | — |
| Solvent | Heptane | HCID 8900 | — |
| Product | 8-(2-Chloro-benzenesulfonyl)-2-(6-ethyl-pyridin-3-yl)-2,8-diaza-spiro[4.5]decan-1-one | HCID 59577884 | — |
Reaction Steps
This material was prepared in analogy to example 1 step D) from 1-(2-chloro-benzenesulfonyl)-4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester, dimethylaluminium chloride in heptane and 6-Ethyl-pyridin-3-ylamine. MS (ESI): 434.3 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08329904B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-e7615616d2b446b99f5f13b216d65d00 |
| Source note | uspto-grants-2012_12 |