HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Trifluoromethoxy)aniline → 2-(4-(Trifluoromethoxy)phenyl)-2,8-diazaspiro[4.5]decan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Trifluoromethoxy)aniline | HCID 600848 | — |
| Reactant | Dimethylalumanylium chloride | HCID 16686359 | — |
| Reactant | 4-(2-Methoxy-ethyl)-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester | HCID 58287261 | — |
| Solvent | Hexane | HCID 8058 | — |
| Product | 2-(4-(Trifluoromethoxy)phenyl)-2,8-diazaspiro[4.5]decan-1-one | HCID 66742759 | — |
Reaction Steps
This material was prepared in analogy to example 1 step D) from 4-(2-methoxy-ethyl)-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester, dimethylaluminium chloride in hexane and 4-trifluoromethoxy-phenylamine, with concomitant cleavage of the Boc protecting group at the reaction conditions applied. MS (ESI): 315.2 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08329904B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-d86a8b5a938c4dc6986b255d4b1d64ac |
| Source note | uspto-grants-2012_12 |