2-(Methylamino)ethanol → 1-Oxo-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decane-8-sulfonic acid (2-hydroxy-ethyl)-methyl-amide

HRID 2194272Notes

Reaction equation

HRID 2194272 reaction equation
[O:1]=[C:2]1[C:6]2([CH2:11][CH2:10][N:9]([S:12](Cl)(=[O:14])=[O:13])[CH2:8][CH2:7]2)[CH2:5][CH2:4][N:3]1[C:16]1[CH:21]=[CH:20][C:19]([O:22][C:23]([F:26])([F:25])[F:24])=[CH:18][CH:17]=1.[CH3:27][NH:28][CH2:29][CH2:30][OH:31]>>[OH:31][CH2:30][CH2:29][N:28]([CH3:27])[S:12]([N:9]1[CH2:10][CH2:11][C:6]2([C:2](=[O:1])[N:3]([C:16]3[CH:21]=[CH:20][C:19]([O:22][C:23]([F:26])([F:25])[F:24])=[CH:18][CH:17]=3)[CH2:4][CH2:5]2)[CH2:7][CH2:8]1)(=[O:14])=[O:13]

Participants

3

Reactant 2

HCID 80162-(Methylamino)ethanolHCID 866476531-Oxo-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decane-8-sulfonyl chloride

Product 1

HCID 595780991-Oxo-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decane-8-sulfonic acid (2-hydroxy-ethyl)-methyl-amide

Procedure

This material was prepared in analogy to example 285 step B) from 1-Oxo-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decane-8-sulfonyl chloride and 2-methylamino-ethanol. The reaction was subjected to work-up and purification after stirring for 2 h at room temperature. MS (ESI): 452.4 (MH+).

Workup

  1. custompurification

Sources & evidence

ORD record
ord-d20e92a3149b411580eb8510aaaa86e0
Source dataset
uspto-grants-2012_12
Patent number
US08329904B2

Reaction notes

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