HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hexane → 2-(4-Cyclopropyl-phenyl)-2,8-diaza-spiro[4.5]decan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hexane | HCID 8058 | — |
| Reactant | Dimethylalumanylium chloride | HCID 16686359 | — |
| Reactant | 4-(2-Methoxy-ethyl)-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester | HCID 58287261 | — |
| Solvent | 4-Cyclopropylaniline | HCID 12253927 | — |
| Product | 2-(4-Cyclopropyl-phenyl)-2,8-diaza-spiro[4.5]decan-1-one | HCID 58287277 | — |
Reaction Steps
This material was prepared in analogy to example 1 step D) from 4-(2-Methoxy-ethyl)-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester, dimethylaluminium chloride in hexane and 4-cyclopropyl-phenylamine, with concomitant cleavage of the Boc protecting group under the reaction conditions. MS (ESI): 271.2 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08329904B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-05398a3a0e9647b5b7a7a64e0c8b3672 |
| Source note | uspto-grants-2012_12 |