Hydrochloric Acid → Diisopropylether ethyl acetate

Participants

Reaction Steps

1 mL of 5 N sodium hydroxide solution was added to tetrahydrofuran:methanol=1:1 (10 mL) solution of 107 mg of ethyl 2-{9-[3-methoxy-4-((5-methyl-2-phenyl-oxazole-4-yl)methoxy)-benzyl]-9H-carbazole-4-yloxy}acetate, and stirred at room temperature for 1 hour. The reaction mixture was diluted with water, adjusted to pH3 by 1 N hydrochloric acid, and extracted with ethyl acetate. The extract was washed with brine, and dried over anhydrous sodium sulfate. After filtration, the filtrate was concentrated in vacuo. The crystals of residue were isolated by filtration with ethyl acetate-diisopropylether, dried under reduced pressure, and 74 mg of the subject compound was prepared as pale yellow crystal.

Provenance & Evidence