4-(4-Chloromethyl-2-methoxyphenoxymethyl)-2-(2-furyl)-5-methyloxazole → HCID 11563484, compound

HRID 2194301Notes

Reaction equation

HRID 2194301 reaction equation
[CH:1]1[C:13]2[NH:12][C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[C:4]([O:14][CH:15]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[C:16]([OH:18])=[O:17])=[CH:3][CH:2]=1.C1C2NC3C(=CC=CC=3)C=2C(OC(C)(C)C(O)=O)=CC=1.Cl[CH2:46][C:47]1[CH:65]=[CH:64][C:50]([O:51][CH2:52][C:53]2[N:54]=[C:55]([C:59]3[O:60][CH:61]=[CH:62][CH:63]=3)[O:56][C:57]=2[CH3:58])=[C:49]([O:66][CH3:67])[CH:48]=1.ClCC1C=CC(OCC2N=C(C3C=CC=CC=3)OC=2C)=C(OC)C=1>>[O:60]1[CH:61]=[CH:62][CH:63]=[C:59]1[C:55]1[O:56][C:57]([CH3:58])=[C:53]([CH2:52][O:51][C:50]2[CH:64]=[CH:65][C:47]([CH2:46][N:12]3[C:13]4[CH:1]=[CH:2][CH:3]=[C:4]([O:14][CH:15]([C:19]5[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=5)[C:16]([OH:18])=[O:17])[C:5]=4[C:6]4[C:11]3=[CH:10][CH:9]=[CH:8][CH:7]=4)=[CH:48][C:49]=2[O:66][CH3:67])[N:54]=1

Participants

5

Reactant 4

HCID 223445974-(4-Chloromethyl-2-methoxyphenoxymethyl)-2-(2-furyl)-5-methyloxazoleHCID 223446094-(4-Chloromethyl-2-methoxyphenoxymethyl)-5-methyl-2-phenyloxazoleHCID 59571738HCID 59571738, compoundHCID 595717422-(9H-carbazole-4-yloxy)-2-methylpropionic acid

Product 1

HCID 11563484HCID 11563484, compound

Procedure

The subject compound was prepared by performing the same operation as that of the example 3 by using 2-(9H-carbazole-4-yloxy)-2-phenylacetic acid prepared by the reference 21 instead of 2-(9H-carbazole-4-yloxy)-2-methylpropionic acid used in the example 3, and using 4-((4-(chloromethyl)-2-methoxyphenoxy)methyl)-2-(furan-2-yl)-5-methyloxazole prepared by the reference 2 instead of 4-((4-(chloromethyl)-2-methoxyphenoxy)methyl)-5-methyl-2-phenyloxazole.

Workup

  1. customThe subject compound was prepared

Sources & evidence

ORD record
ord-0716b7fdc6c34585bcce96f1bb025865
Source dataset
uspto-grants-2012_12
Patent number
US08329913B2

Reaction notes

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