4-(4-Chloromethyl-2-methoxyphenoxymethyl)-5-methyl-2-phenyloxazole → HCID 11556143, compound

HRID 2194304Notes

Reaction equation

HRID 2194304 reaction equation
[CH:1]1[C:13]2[NH:12][C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[C:4]([O:14][CH2:15][C:16]([CH3:21])([CH3:20])[C:17]([OH:19])=[O:18])=[CH:3][CH:2]=1.C1C2NC3C(=CC=CC=3)C=2C(OC(C)(C)C(O)=O)=CC=1.Cl[CH2:43][C:44]1[CH:63]=[CH:62][C:47]([O:48][CH2:49][C:50]2[N:51]=[C:52]([C:56]3[CH:61]=[CH:60][N:59]=[CH:58][CH:57]=3)[O:53][C:54]=2[CH3:55])=[C:46]([O:64][CH3:65])[CH:45]=1.ClCC1C=CC(OCC2N=C(C3C=CC=CC=3)OC=2C)=C(OC)C=1>>[CH3:65][O:64][C:46]1[CH:45]=[C:44]([CH:63]=[CH:62][C:47]=1[O:48][CH2:49][C:50]1[N:51]=[C:52]([C:56]2[CH:57]=[CH:58][N:59]=[CH:60][CH:61]=2)[O:53][C:54]=1[CH3:55])[CH2:43][N:12]1[C:13]2[CH:1]=[CH:2][CH:3]=[C:4]([O:14][CH2:15][C:16]([CH3:21])([CH3:20])[C:17]([OH:19])=[O:18])[C:5]=2[C:6]2[C:11]1=[CH:10][CH:9]=[CH:8][CH:7]=2

Participants

5

Reactant 4

HCID 223446094-(4-Chloromethyl-2-methoxyphenoxymethyl)-5-methyl-2-phenyloxazoleHCID 595717393-(9H-carbazole-4-yloxy)-2,2-dimethylpropionic acidHCID 595717422-(9H-carbazole-4-yloxy)-2-methylpropionic acidHCID 595717614-((4-(Chloromethyl)-2-methoxyphenoxy)methyl)-2-(pyridine-4-yl)-5 methyloxazole

Product 1

HCID 11556143HCID 11556143, compound

Procedure

The subject compound was prepared by performing the same operation as that of the example 3 by using 3-(9H-carbazole-4-yloxy)-2,2-dimethylpropionic acid prepared by the reference 30 instead of 2-(9H-carbazole-4-yloxy)-2-methylpropionic acid used in the example 3, and using 4-((4-(chloromethyl)-2-methoxyphenoxy)methyl)-2-(pyridine-4-yl)-5 methyloxazole prepared by the reference 4 instead of 4-((4-(chloromethyl)-2-methoxyphenoxy)methyl)-5-methyl-2-phenyloxazole.

Workup

  1. customThe subject compound was prepared

Sources & evidence

ORD record
ord-219269a65ffa4a459568a8620955b3d1
Source dataset
uspto-grants-2012_12
Patent number
US08329913B2

Reaction notes

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