Hydrochloric Acid → HCID 11713948, compound

Participants

Reaction Steps

440 mg of ethyl (S)-(+)-2-{9-[3-methoxy-4-(5-methyl-2-phenyl-oxazole-4-ylmethoxy)-benzyl]-9H-carbazole-4-yloxy}butyrate was suspended in ethanol (4.4 mL), 175 μL of 5 N sodium hydroxide solution was added thereto, and stirred at room temperature for 4 hours. The reaction mixture was diluted with water, and adjusted to pH3 with 1 N hydrochloric acid, and extracted with ethyl acetate. The extract was washed with brine, and dried over anhydrous sodium sulfate. After filtration, the filtrate was concentrated in vacuo, and 420 mg of the subject compound was prepared as white solid. Optical purity 95% ee (HPLC).

Provenance & Evidence