Potassium Carbonate → HCID 67238087, compound

Participants

Reaction Steps

1.45 g (9.24 mmol) of 2-chloro-4-hydroxy-5-methylaniline are introduced into 18 ml of acetonitrile, treated with 1.53 g (11.08 mmol) of potassium carbonate at ambient temperature and stirred at ambient temperature for 30 min. Subsequently, 3.50 g (9.24 mmol) of 3-[2-(4-chlorophenyl)ethyl]-5-[(4-methylphenyl]sulphonyl]-1,2,4-thiadiazole are added and the reaction mixture is stirred at 50° C. for 12 h. After cooling, the mixture is concentrated on a rotary evaporator, the residue is taken up in dichloromethane and the solution is extracted twice with water, dried over Na2SO4 and freed from the solvent under vacuum. 3.11 g of product are obtained (94.3% purity, 83.4% yield, log P (pH 2.3)=4.50).

Provenance & Evidence