Dimethyl Sulfoxide → HCID 86645800, compound

HRID 2194342Notes

Reaction equation

HRID 2194342 reaction equation
[CH:1]1[C:2]2[C:16](=[O:17])[C:15]3[C:14]([OH:18])=[C:13]([O:19][C@@H:20]4[O:25][C@H:24]([CH2:26][OH:27])[C@@H:23]([OH:28])[C@H:22]([OH:29])[C@H:21]4[OH:30])[C:12]([OH:31])=[CH:11][C:10]=3[O:9][C:3]=2[CH:4]=[C:5]([OH:8])[C:6]=1[OH:7].CS(C)=O.[OH-].[Ca+2:37].[OH-].C(O)C>OCC(CO)O>[CH:1]1[C:2]2[C:16](=[O:17])[C:15]3[C:14]([OH:18])=[C:13]([O:19][C@@H:20]4[O:25][C@H:24]([CH2:26][OH:27])[C@@H:23]([OH:28])[C@H:22]([OH:29])[C@H:21]4[OH:30])[C:12]([OH:31])=[CH:11][C:10]=3[O:9][C:3]=2[CH:4]=[C:5]([OH:8])[C:6]=1[OH:7].[Ca:37]

Participants

6

Reactant 4

HCID 679Dimethyl SulfoxideHCID 702EthanolHCID 5319258HCID 5319258, compound2×HCID 6093208Calcium Hydroxide2×

Product 1

HCID 86645800HCID 86645800, compound

Reagents, catalysts & solvents 1

HCID 753GlycerolSolvent

Conditions

Temperature
60 °C

Procedure

mangiferin 4.2 g (0.01 mol) is dissolved into 50 ml DMSO, calcium hydroxide 0.37 g (0.005 mol) is dissolved in 80 g glycerol, calcium hydroxide solution is added slowly into mangiferin solution while mixing round, mixing round until it react completely. Appropriate quantity ethanol is added into the reaction solution, mixing round adequately. A lot of deposition is come into being in solution. The reaction solution is filtrated to get the deposition. This deposition is heated up no excess 60° C. to dry. The yellow green solid substance is mangiferin calcium. Its weight is 3.8 g, the productivity is 90.4%. The purity of mangiferin monopotassium is 71.2% detected by HPLC.

Workup

  1. additionwhile mixing round
  2. additionmixing round until it
  3. customreact completely
  4. additionmixing round adequately
  5. filtrationThe reaction solution is filtrated
  6. customto get the deposition
  7. customto dry

Sources & evidence

ORD record
ord-feb9bfca815a4843a343b92bbb418e1e
Source dataset
uspto-grants-2012_12
Patent number
US08334267B2

Reaction notes

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