HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2194352Generated: October 30, 2026
Benzylethanolamine → (R)-(-)-5-((Benzyl(2-hydroxyethyl)amino)methyl)pyrrolidin-2-one
https://huagongshe.com/reaction/2194352
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzylethanolamine | HCID 4348 | — |
| Reactant | (R)-(5-oxopyrrolidin-2-yl)methyl methanesulfonate | HCID 13306709 | — |
| Product | (R)-(-)-5-((Benzyl(2-hydroxyethyl)amino)methyl)pyrrolidin-2-one | HCID 66865389 | 98.3% |
Reaction Steps
A mixture of (−)-methanesulfonic acid (R)-5-oxo-pyrrolidin-2-ylmethyl ester (10.53 g, 54.5 mmol) and 2-(benzylamino)ethanol (32.58 g, 215.5 mmol) was heated at 130° C. in a microwave oven (Personal Chemistry Emrys™ Optimizer) for 45 minutes. The residue was partitioned between water and DCM, the organic phase was washed with brine, dried (Na2SO4) and evaporated under vacuum. The crude was purified by flash chromatography (DCM/MeOH 95/5 respectively) to afford the title compound as yellow oil (13.3 g, 98% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08334286B2 |
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| Source dataset | uspto-grants-2012_12 |
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| ORD ID | ord-5fa12628e48240a0bb38eb2dee07a9ae |
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| Source note | uspto-grants-2012_12 |
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