4-Pyrazin-2-yl-butyric acid ethyl ester → Hexahydro-1H-pyrido[1,2-a]pyrazin-6(2H)-one

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Reaction Steps

4-Pyrazin-2-yl-butyric acid ethyl ester (1 g, 5.14 mmol) was dissolved in abs. EtOH (50 ml) and hydrogenated over 10% Pd/C (200 mg) at 50 psi for 20 hours. After filtration, the solvent was removed under vacuum and the residue was purified by flash chromatography (DCM/MeOH/32% NH4OH from 95/5/0.5 to 90/10/1 respectively) to afford the title compound (454 mg, 57% yield).

Provenance & Evidence