Pyrrolidone carboxylic acid → Methyl 5-oxo-DL-prolinate

Participants

Reaction Steps

A mixture of 5-oxo-pyrrolidine-2-carboxylic acid (5 g, 38.7 mmol) and Amberlyst® 15 (5 g) in MeOH (50 ml) was refluxed for 20 hours. After cooling, the reaction was filtered and the solvent removed under vacuum to afford the title compound (4.9 g, 90% yield) that was used without further purification in the next step.

Provenance & Evidence