1,1'-Carbonyldiimidazole → HCID 44192926, compound

Participants

Reaction Steps

To a solution of 3-methyl-isoxazole-5-carboxylic acid (100 mg, 0.79 mmol) in CH3CN (10 ml), carbonyldiimidazole (140 mg, 0.87 mmol) was added at room temperature. After stirring for 1 hour, a solution of (S)-(−)-hexahydropyrrolo[1,2-a]pyrazin-6(7H)-one (compound of Description 5, 121 mg, 0.86 mmol) in CH3CN (2 ml), was added dropwise at room temperature. After stirring the solution for 20 hours, the solvent was removed under vacuum and the residue purified by flash chromatography (DCM/MeOH 95/5 respectively) to afford the title compound as an oil (160 mg, 82% yield).

Provenance & Evidence