反应详情

1.97 g (7.43 mmol) of 5-[[(benzyloxy)carbonyl](methyl)amino]valeric acid are dissolved in 30 ml of dichloromethane, and 4.9 ml (67.3 mmol) of thionyl chloride are added. The mixture is heated under reflux for 1 h. It is then concentrated in vacuo, and the residue is again mixed with dichloromethane and concentrated once again. A viscous oil remains and is dried under high vacuum. 2 g (95% of theory) of the target compound are obtained and are reacted further without further purification and characterization.

1. temperatureThe mixture is heated
2. temperatureunder reflux for 1 h
3. concentrationIt is then concentrated in vacuo
4. additionthe residue is again mixed with dichloromethane
5. concentrationconcentrated once again
6. customA viscous oil remains and is dried under high vacuum
7. custom2 g (95% of theory) of the target compound are obtained
8. customare reacted further without further purification and characterization