HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → N-[(2-Aminoethoxy)acetyl]-5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Perchloric Acid | HCID 24247 | — |
| Reactant | Rivaroxaban | HCID 9875401 | — |
| Reactant | (S)-4-(4-(5-(aminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one | HCID 11346837 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | N-[(2-Aminoethoxy)acetyl]-5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide hydrochloride | HCID 66674124 | — |
Reaction Steps
Agilent 1100 with DAD (G1315A), quat. pump (G1311A), autosampler CTC HTS PAL, degasser (G1322A) and column thermostat (G1316A); column. Zorbax Extend-C18 3.5μ; temperature: 40° C.; eluent A: water+5 ml of perchloric acid/litre, eluent B: acetonitrile; flow rate: 0.7 ml/min; gradient: 0-0.5 min 98% A, 2% B; ramp 0.5-4.5 min 10% A, 90% B; 4.5-6 min 10% A, 90% B; ramp 6.5-6.7 min 98% A, 2% B; 6.7-7.5 min 98% A, 2% B.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08334284B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-a2df08a9d1844587940cd1e74c6c7293 |
| Source note | uspto-grants-2012_12 |