Iodoethanol → 4-[4-(3-chloro-phenylethynyl)-2-methyl-imidazol-1-yl]-1-(2-hydroxy-ethyl)-1H-pyridin-2-one

HRID 2194388Notes

Reaction equation

HRID 2194388 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]#[C:9][C:10]2[N:11]=[C:12]([CH3:22])[N:13]([C:15]3[CH:20]=[CH:19][NH:18][C:17](=[O:21])[CH:16]=3)[CH:14]=2)[CH:5]=[CH:6][CH:7]=1.I[CH2:24][CH2:25][OH:26]>>[Cl:1][C:2]1[CH:3]=[C:4]([C:8]#[C:9][C:10]2[N:11]=[C:12]([CH3:22])[N:13]([C:15]3[CH:20]=[CH:19][N:18]([CH2:24][CH2:25][OH:26])[C:17](=[O:21])[CH:16]=3)[CH:14]=2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 12225IodoethanolHCID 498725744-[4-(3-chloro-phenylethynyl)-2-methyl-imidazol-1-yl]-1H-pyridin-2-one

Product 1

HCID 581111934-[4-(3-chloro-phenylethynyl)-2-methyl-imidazol-1-yl]-1-(2-hydroxy-ethyl)-1H-pyridin-2-one

Procedure

The title compound, orange gum, MS: m/e=354.2, 356.2 (M+H+), was prepared in accordance with the general method of example 3 from 4-[4-(3-chloro-phenylethynyl)-2-methyl-imidazol-1-yl]-1H-pyridin-2-one and 2-iodoethanol.

Sources & evidence

ORD record
ord-5b727d2e03d84d329205ee1523010d41
Source dataset
uspto-grants-2012_12
Patent number
US08334287B2

Reaction notes

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