Potassium Hydroxide → HCID 58111205, compound

HRID 2194389Notes

Reaction equation

HRID 2194389 reaction equation
Cl[C:2]1[CH:7]=[C:6]([N:8]2[CH:12]=[C:11]([C:13]#[C:14][C:15]3[CH:20]=[CH:19][N:18]=[C:17]([Cl:21])[CH:16]=3)[N:10]=[C:9]2[CH3:22])[CH:5]=[CH:4][N:3]=1.[OH-:23].[K+]>C(O)(C)(C)C>[Cl:21][C:17]1[CH:16]=[C:15]([C:14]#[C:13][C:11]2[N:10]=[C:9]([CH3:22])[N:8]([C:6]3[CH:5]=[CH:4][NH:3][C:2](=[O:23])[CH:7]=3)[CH:12]=2)[CH:20]=[CH:19][N:18]=1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 86649880HCID 86649880, compound

Product 1

HCID 58111205HCID 58111205, compound

Reagents, catalysts & solvents 1

HCID 6386tert-ButanolSolvent

Procedure

The title compound, white crystalline solid, MS: m/e=311.2, 313.2 (M+H+), was prepared in accordance with the general method of example 1a by treatment of 2-chloro-4-[4-(2-chloro-pyridin-4-ylethynyl)-2-methyl-imidazol-1-yl]-pyridine with 50% KOH in tert-butanol

Sources & evidence

ORD record
ord-d6fb3d6027c7425e8d0246b54f1083bc
Source dataset
uspto-grants-2012_12
Patent number
US08334287B2

Reaction notes

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