2-Chloro-4-fluoropyridine → HCID 86649880, compound

HRID 2194390Notes

Reaction equation

HRID 2194390 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]#[C:9][C:10]2[N:11]=[C:12]([CH3:15])[NH:13][CH:14]=2)[CH:5]=[CH:4][N:3]=1.[Cl:16][C:17]1[CH:22]=[C:21](F)[CH:20]=[CH:19][N:18]=1>>[Cl:16][C:17]1[CH:22]=[C:21]([N:13]2[CH:14]=[C:10]([C:9]#[C:8][C:6]3[CH:5]=[CH:4][N:3]=[C:2]([Cl:1])[CH:7]=3)[N:11]=[C:12]2[CH3:15])[CH:20]=[CH:19][N:18]=1

Participants

3

Reactant 2

HCID 27827922-Chloro-4-fluoropyridineHCID 178418879HCID 178418879, compound

Product 1

HCID 86649880HCID 86649880, compound

Procedure

The title compound, white crystalline solid, MS: m/e=329.2, 331.1 (M+H+) was prepared in accordance with the general method of example 1b from 2-chloro-4-(2-methyl-1H-imidazol-4-ylethynyl)-pyridine (CAS: [802905-83-5]) and 2-chloro-4-fluoropyridine.

Sources & evidence

ORD record
ord-30c77af6563244d285341d5842340068
Source dataset
uspto-grants-2012_12
Patent number
US08334287B2

Reaction notes

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