2-Chloro-4-fluoropyridine → 2-Chloro-4-(2-methyl-4-m-tolylethynyl-imidazol-1-yl)-pyridine

HRID 2194393Notes

Reaction equation

HRID 2194393 reaction equation
[CH3:1][C:2]1[NH:3][CH:4]=[C:5]([C:7]#[C:8][C:9]2[CH:10]=[C:11]([CH3:15])[CH:12]=[CH:13][CH:14]=2)[N:6]=1.[Cl:16][C:17]1[CH:22]=[C:21](F)[CH:20]=[CH:19][N:18]=1>>[Cl:16][C:17]1[CH:22]=[C:21]([N:3]2[CH:4]=[C:5]([C:7]#[C:8][C:9]3[CH:10]=[C:11]([CH3:15])[CH:12]=[CH:13][CH:14]=3)[N:6]=[C:2]2[CH3:1])[CH:20]=[CH:19][N:18]=1

Participants

3

Reactant 2

HCID 27827922-Chloro-4-fluoropyridineHCID 178424902HCID 178424902, compound

Product 1

HCID 866498812-Chloro-4-(2-methyl-4-m-tolylethynyl-imidazol-1-yl)-pyridine

Procedure

The title compound, light brown solid, MS: m/e=308.2, 310.1 (M+H+) was prepared in accordance with the general method of example 1b from 2-Methyl-4-m-tolylethynyl-1H-imidazole and 2-chloro-4-fluoropyridine

Sources & evidence

ORD record
ord-6162accd8436405ebccb93c94bf14c73
Source dataset
uspto-grants-2012_12
Patent number
US08334287B2

Reaction notes

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