Ethyl bromoacetate → [4-(2-Methyl-4-m-tolylethynyl-imidazol-1-yl)-2-oxo-2H-pyridin-1-yl]-acetic acid ethyl ester

HRID 2194399Notes

Reaction equation

HRID 2194399 reaction equation
[CH3:1][C:2]1[N:3]([C:16]2[CH:21]=[CH:20][NH:19][C:18](=[O:22])[CH:17]=2)[CH:4]=[C:5]([C:7]#[C:8][C:9]2[CH:10]=[C:11]([CH3:15])[CH:12]=[CH:13][CH:14]=2)[N:6]=1.Br[CH2:24][C:25]([O:27][CH2:28][CH3:29])=[O:26]>>[CH2:28]([O:27][C:25](=[O:26])[CH2:24][N:19]1[CH:20]=[CH:21][C:16]([N:3]2[CH:4]=[C:5]([C:7]#[C:8][C:9]3[CH:10]=[C:11]([CH3:15])[CH:12]=[CH:13][CH:14]=3)[N:6]=[C:2]2[CH3:1])=[CH:17][C:18]1=[O:22])[CH3:29]

Participants

3

Reactant 2

HCID 7748Ethyl bromoacetateHCID 498726724-(2-Methyl-4-m-tolylethynyl-imidazol-1-yl)-1H-pyridin-2-one

Product 1

HCID 49872676[4-(2-Methyl-4-m-tolylethynyl-imidazol-1-yl)-2-oxo-2H-pyridin-1-yl]-acetic acid ethyl ester

Procedure

The title compound, brown solid, MS: m/e=376.3 (M+H+), was prepared in accordance with the general method of example 3 from 4-(2-Methyl-4-m-tolylethynyl-imidazol-1-yl)-1H-pyridin-2-one and ethyl bromoacetate.

Sources & evidence

ORD record
ord-5cd24ff9cdbf405ba7e8b73fe909b757
Source dataset
uspto-grants-2012_12
Patent number
US08334287B2

Reaction notes

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