Potassium Hydroxide → HCID 178432692, compound

HRID 2194400Notes

Reaction equation

HRID 2194400 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]#[C:9][C:10]2[N:11]=[C:12]([CH3:22])[N:13]([C:15]3[CH:20]=[CH:19][CH:18]=[C:17](F)[N:16]=3)[CH:14]=2)[CH:5]=[CH:6][CH:7]=1.[OH-:23].[K+]>C(O)(C)(C)C>[Cl:1][C:2]1[CH:3]=[C:4]([C:8]#[C:9][C:10]2[N:11]=[C:12]([CH3:22])[N:13]([C:15]3[N:16]=[C:17]([OH:23])[CH:18]=[CH:19][CH:20]=3)[CH:14]=2)[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 589062992-[4-[2-(3-Chlorophenyl)ethynyl]-2-methyl-1H-imidazol-1-yl]-6-fluoropyridine

Product 1

HCID 178432692HCID 178432692, compound

Reagents, catalysts & solvents 1

HCID 6386tert-ButanolSolvent

Procedure

The title compound, light yellow solid, MS: m/e=310.1, 312.0 (M+H), was prepared in accordance with the general method of example 1a from 2-[4-(3-chloro-phenylethynyl)-2-methyl-imidazol-1-yl]-6-fluoro-pyridine and KOH in tert-butanol.

Sources & evidence

ORD record
ord-975ed312c81443628a4e32c69821ee9f
Source dataset
uspto-grants-2012_12
Patent number
US08334287B2

Reaction notes

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