Methyl iodide → HCID 49872866, compound

HRID 2194402Notes

Reaction equation

HRID 2194402 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]#[C:9][C:10]2[N:11]=[C:12]([CH3:22])[N:13]([C:15]3[N:20]=[C:19]([OH:21])[CH:18]=[CH:17][CH:16]=3)[CH:14]=2)[CH:5]=[CH:6][CH:7]=1.[CH3:23]I>>[Cl:1][C:2]1[CH:3]=[C:4]([C:8]#[C:9][C:10]2[N:11]=[C:12]([CH3:22])[N:13]([C:15]3[N:20]([CH3:23])[C:19](=[O:21])[CH:18]=[CH:17][CH:16]=3)[CH:14]=2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 178432692HCID 178432692, compound

Product 1

HCID 49872866HCID 49872866, compound

Procedure

The title compound, off-white cristalline solid, MS: m/e=324.2, 326.1 (M+H), was prepared in accordance with the general method of example 3 from 6-[4-(3-chloro-phenylethynyl)-2-methyl-imidazol-1-yl]-pyridin-2-ol and methyl iodide, along with the O-alkylation product from which it was separated by flash chromatography (gradient: EtOAc to EtOAc/MeOH 95:5).

Sources & evidence

ORD record
ord-4e1f5041022946cdab31e66f5efd1e3a
Source dataset
uspto-grants-2012_12
Patent number
US08334287B2

Reaction notes

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