Potassium Hydroxide → HCID 178432713, compound

HRID 2194405Notes

Reaction equation

HRID 2194405 reaction equation
F[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([N:8]2[CH:12]=[C:11]([C:13]#[C:14][C:15]3[CH:20]=[CH:19][N:18]=[C:17]([Cl:21])[CH:16]=3)[N:10]=[C:9]2[CH3:22])[N:3]=1.[OH-:23].[K+]>C(O)(C)(C)C>[Cl:21][C:17]1[CH:16]=[C:15]([C:14]#[C:13][C:11]2[N:10]=[C:9]([CH3:22])[N:8]([C:4]3[N:3]=[C:2]([OH:23])[CH:7]=[CH:6][CH:5]=3)[CH:12]=2)[CH:20]=[CH:19][N:18]=1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 86649882HCID 86649882, compound

Product 1

HCID 178432713HCID 178432713, compound

Reagents, catalysts & solvents 1

HCID 6386tert-ButanolSolvent

Procedure

The title compound, white cristalline solid, MS: m/e=311.2, 313.2 (M+H+), was prepared in accordance with the general method of example 1a from 2-fluoro-6-[4-(2-chloro-pyridin-4-ylethynyl)-2-methyl-imidazol-1-yl]-pyridine and KOH in tert-butanol.

Sources & evidence

ORD record
ord-5410d69223a745ac83ae7beb17a7d4b4
Source dataset
uspto-grants-2012_12
Patent number
US08334287B2

Reaction notes

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