3-Methylphenylacetylene → 2-ethyl-5-(2-methyl-4-m-tolylethynyl-imidazol-1-yl)-2H-pyridazin-3-one

HRID 2194452Notes

Reaction equation

[CH2:1]([N:3]1[C:8](=[O:9])[CH:7]=[C:6]([N:10]2[CH:14]=[C:13](I)[N:12]=[C:11]2[CH3:16])[CH:5]=[N:4]1)[CH3:2].[C:17]([C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([CH3:25])[CH:20]=1)#[CH:18]>>[CH2:1]([N:3]1[C:8](=[O:9])[CH:7]=[C:6]([N:10]2[CH:14]=[C:13]([C:18]#[C:17][C:19]3[CH:20]=[C:21]([CH3:25])[CH:22]=[CH:23][CH:24]=3)[N:12]=[C:11]2[CH3:16])[CH:5]=[N:4]1)[CH3:2]

Participants

Reactant 2

HCID 1366003-Methylphenylacetylene

HCID 668657362-ethyl-5-(4-iodo-2-methyl-imidazol-1-yl)-2H-pyridazin-3-one

Product 1

HCID 498728622-ethyl-5-(2-methyl-4-m-tolylethynyl-imidazol-1-yl)-2H-pyridazin-3-one

Procedure

The title compound, light brown crystalline solid, MS: m/e=319.1 (M+), was prepared in accordance with the general method of example 21a from 2-ethyl-5-(4-iodo-2-methyl-imidazol-1-yl)-2H-pyridazin-3-one and 1-ethynyl-3-methyl-benzene.

Sources & evidence

ORD record: ord-8fe4b779d7c24d78adaa0be409f91f2e
Source dataset: uspto-grants-2012_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08334287B2

Reaction notes

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