2-Chloro-4-(2-(trimethylsilyl)ethynyl)pyridine → 5-[4-(2-chloro-pyridin-4-ylethynyl)-2-methyl-imidazol-1-yl]-2-ethyl-2H-pyridazin-3-one

HRID 2194458Notes

Reaction equation

HRID 2194458 reaction equation
[CH2:1]([N:3]1[C:8](=[O:9])[CH:7]=[C:6]([N:10]2[CH:14]=[C:13](I)[N:12]=[C:11]2[CH3:16])[CH:5]=[N:4]1)[CH3:2].[Cl:17][C:18]1[CH:23]=[C:22]([C:24]#[C:25][Si](C)(C)C)[CH:21]=[CH:20][N:19]=1>>[Cl:17][C:18]1[CH:23]=[C:22]([C:24]#[C:25][C:13]2[N:12]=[C:11]([CH3:16])[N:10]([C:6]3[CH:5]=[N:4][N:3]([CH2:1][CH3:2])[C:8](=[O:9])[CH:7]=3)[CH:14]=2)[CH:21]=[CH:20][N:19]=1

Participants

3

Reactant 2

HCID 219853912-Chloro-4-(2-(trimethylsilyl)ethynyl)pyridineHCID 668657362-ethyl-5-(4-iodo-2-methyl-imidazol-1-yl)-2H-pyridazin-3-one

Product 1

HCID 581112025-[4-(2-chloro-pyridin-4-ylethynyl)-2-methyl-imidazol-1-yl]-2-ethyl-2H-pyridazin-3-one

Procedure

The title compound, light yellow crystalline solid, MS: m/e=339.1, 340.6 (M+H+), was prepared in accordance with the general method of example 35 from 2-ethyl-5-(4-iodo-2-methyl-imidazol-1-yl)-2H-pyridazin-3-one and 2-chloro-4-trimethylsilanylethynyl-pyridine.

Sources & evidence

ORD record
ord-b2b4a8b42a784ef2b104f3ed34ea2e64
Source dataset
uspto-grants-2012_12
Patent number
US08334287B2

Reaction notes

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