Bromide ion → HCID 25254221, compound

Participants

Reaction Steps

Example 3b (50 mg, 0.139 mmol) was reacted with BCl3 (1.1 eq.) according to General Procedure C. The material thus obtained was then reacted with 1,2-dibromoethane (3.0 eq.) according to General Procedure F and the product bromide reacted with morpholine according to General Procedure G to afford the product as a clear oil (21 mg, 33% over 3 steps). 1H NMR (300 MHz, CDCl3) δ 7.19-7.14 (m, 2H), 6.98-6.93 (m, 2H), 4.09-4.00 (m, 4H), 3.77 (s, 3H), 3.71-3.68 (m, 4H), 2.79 (t, J=7.4 Hz, 2H), 2.62 (t, J=5.7 Hz, 2H), 2.50 (s, 3H), 2.49-2.46 (m, 4H), 2.11 (s, 3H), 2.05 (s, 3H), 2.05-1.97 (m, 2H).

Provenance & Evidence