2-(Pyridin-2-yl)ethyl methanesulfonate → 1-[3-Chloro-5-[3-(4-fluoro-phenyl)-butoxy]-4-methoxy-2-methyl-6-(2-pyridin-2-yl-ethoxy)-phenyl]-ethanone

Participants

Reaction Steps

Example 7c (500 mg, 1.31 mmol) was reacted with 2-pyridin-2-ylethyl methanesulfonate (2.0 eq.) as described under General Procedure F to give the title compound as an oil (410 mg, 89%). 1H NMR (300 MHz, CDCl3) δ 8.52 (d, J=4.1 Hz, 1H), 7.58 (dt, J=7.7, 1.8 Hz, 1H), 7.17-7.10 (m, 4H), 6.97-6.90 (m, 2H), 4.37 (t, J=6.6 Hz, 2H), 3.85 (t, J=6.6 Hz, 2H), 3.81 (s, 3H), 3.10 (t, J=6.5 Hz, 2H), 2.98-2.91 (m, 1H), 2.26 (s, 3H), 2.14 (s, 3H), 1.96-1.88 (m, 2H), 1.25 (d, J=7.0 Hz, 3H). MS (ES+) m/z 485.9 (M+H+).

Provenance & Evidence