Dimethyl malonate → HCID 67010726, compound

Participants

Reaction Conditions

Reaction Steps

8.66 g (64.5 mmol) of 2-(methylamino)nicotinaldehyde was dissolved in methanol (100 mL), and 12.68 g (96.0 mmol) of dimethyl malonate and 2.18 g (25.6 mmol) of piperidine were added to the solution. The resulting mixture was stirred for 7 hours at 80° C. The mixture was cooled, and a solid precipitated therefrom was separated by filtration. The solid was washed with diisopropyl ether, and thus 11.71 g (yield: 84%) of the title compound was obtained as a pale yellow solid.

Provenance & Evidence