Hydrochloric Acid → HCID 67009554, compound

Participants

Reaction Conditions

Reaction Steps

2.81 g (10.1 mmol) of methyl 1-(ethylthiomethyl)-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate was dissolved in 1,4-dioxane (70 mL), and 6 N hydrochloric acid (20 mL) was added thereto at room temperature. The resulting mixture was stirred for 3 hours at 50° C. The solvent of the reaction mixture was distilled off under reduced pressure, and the residue thus obtained was washed sequentially with water and diisopropyl ether. Thus, 2.20 g of the title compound was obtained as pale yellow crystals (yield: 82%).

Provenance & Evidence